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Coffee May Cause Miscarriage |
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January 24, 2008 -- A high intake of caffeine during pregnancy increased the risk for miscarriage, according to the results of a population-based, prospective cohort study reported in the January 21 Online First issue of the American Journal of Obstetrics & Gynecology.
"Caffeine can readily cross the placental barrier to the fetus; its clearance is prolonged in pregnant women, and its metabolism rate is low in the fetus because of low levels of enzymes," write Xiaoping Weng, PhD, from Kaiser Permanente in Oakland, California, and colleagues. "Although numerous studies on maternal caffeine consumption and the risk of miscarriage have been published since the 1980s, the effect of caffeine intake on the risk of miscarriage remains controversial because of methodological limitations. . . . The objective of this population-based prospective study was to examine the effect of maternal caffeine intake during pregnancy on the risk of miscarriage, taking into account a number of potential confounders, especially the impact of nausea or vomiting during pregnancy." |
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